Christopher G Earnhart Selected Research

1-oleoyl-2-stearoylphosphatidylcholine

1/2020	Development and optimization of OspC chimeritope vaccinogens for Lyme disease.
1/2019	Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.
1/2017	Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development.
12/2016	Antibody profiling of canine IgG responses to the OspC protein of the Lyme disease spirochetes supports a multivalent approach in vaccine and diagnostic assay development.
6/2011	Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate.
4/2010	Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.
1/2007	Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.
12/2005	Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response.

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Christopher G Earnhart Research Topics

Disease

7	Infections 01/2022 - 12/2005
5	Lyme Disease (Disease, Lyme) 01/2020 - 12/2005
2	COVID-19 03/2022 - 01/2022
2	Relapsing Fever 08/2014 - 07/2011
1	Botulism 01/2019

Drug/Important Bio-Agent (IBA)

8	1-oleoyl-2-stearoylphosphatidylcholineIBA 01/2020 - 12/2005
6	EpitopesIBA 01/2022 - 12/2005
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2016
4	OspC proteinIBA 01/2019 - 12/2005
3	VaccinesIBA 01/2017 - 12/2005
2	AntibodiesIBA 03/2022 - 01/2022
2	Monoclonal AntibodiesIBA 03/2022 - 01/2019
2	Lipoproteins (Lipoprotein)IBA 01/2017 - 06/2011
2	Virulence Factors (Pathogenicity Factors)IBA 08/2014 - 12/2005
1	Neutralizing AntibodiesIBA 03/2022
1	ADM03820IBA 03/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	AerosolsIBA 01/2019
1	AntigensIBA 01/2017
1	Subunit VaccinesIBA 01/2017
1	OspA proteinIBA 01/2017
1	Immunoglobulin G (IgG)IBA 12/2016
1	Green Fluorescent ProteinsIBA 07/2011
1	LigandsIBA 04/2010

Therapy/Procedure

1	Therapeutics 03/2022